We are pleased to have Professor Angus Lamond, who is a Professor of Biochemistry at the University of Dundee, as our BSPR Lecturer. Angus and his colleagues study pre-mRNA splicing, gene regulation and disease mechanisms in both human cells and model organisms. He has a long-standing interest in applying quantitative, mass spectrometry-based proteomics methods to characterise cell phenotypes and biological responses. Angus’ group have developed robust methods for studying cell proteomes at a multidimensional level, integrating data on protein isoform expression, subcellular localisation, post-translational modifications, protein complex formation and protein turnover. During the past 15 years Angus has also become fascinated by the challenges of analysing and integrating ‘Big Data’ generated in proteomics studies with cognate information from other omics, imaging and cellular studies. This has led Angus and his group to develop new computational tools, including the ‘Encyclopedia of Proteome Dynamics’ (EPD). This is an integrated analytics repository that provides a searchable, open access data sharing tool using advanced data science technologies.
As the BSPR Lecturer, Angus is presenting lectures that build on his interests in applying multidimensional proteomics and data science technologies to characterise biological systems and disease mechanisms. The lectures focus on recent data from Angus and his colleagues and collaborators studying the large set of high quality human iPS cell lines developed by the HipSci consortium (see; www.hipsci.org). This study on iPS cells derived from both healthy human donors, as well as specific disease cohorts of donors with inherited disorders, allows the characterisation of human proteomes in health and disease. The data reveal natural variations in human proteomes between healthy individuals and how the proteomic landscape is remodelled by mutations causing disease. The proteome data also have been integrated with parallel transcriptome RNA expression data and exome sequence data from the same cell lines, providing a detailed picture of how gene expression is coordinated. All of these data have been integrated within the EPD database for convenient interactive exploration, providing an example of how large, complex datasets can be integrated and shared effectively with the community.
Angus gave the first of his BSPR lectures at the University of St Andrews on April 24th, 2019. The lecture was entitled, “Genetic Analysis of Human iPS Cells; Generating Deep Proteomes & Navigating the Data Mountain”. His lectures so far are listed below. The lectures are designed to be accessible to a wide general audience and if you are interested in Angus presenting one of these lectures at your University while he is the BSPR Lecturer, please contact him at ‘[email protected]’.
BSPR Lectures 2019
24th April – University of St Andrews
1st May – University of Cambridge
6th June – Barts Cancer Institute, London
1-3 July – BSPR Annual Conference, Southampton
Future Lectures Scheduled include:
25-26th Sept – SULSA Conference, Edinburgh